Away from the Premier League, the last-16 draw was held for the prestigious Uefa Youth League earlier.
Amongst the most eye-catching ties is a meeting between Liverpool and Manchester United.
That means former England team-mates Steven Gerrard and Nicky Butt going head-to-head in the dug-out.
The game will be played at Tranmere on Wednesday, 21 February. The winner will visit either Manchester City or Inter Milan in the quarter-finals.