Warrington's reward for clinging on against Wigan Warriors is an away fixture against Hull KR, while Bradford Bulls get an all-Championship fixture at home to Halifax.
Championship side Bradford shocked Super League Leeds Rhinos to reach the quarter-finals of the Challenge Cup.
They led 22-14 at half-time thanks to tries from Dalton Grant, Jake Webster, Sam Hallas and Mikey Wood and defended for their lives after the break.
The Rhinos, who have Richard Agar in caretaker charge after the sacking of David Furner, almost forced extra-time when Tom Briscoe crossed late on.
But Liam Sutcliffe's conversion hit the post, and the Bulls held out.
Read the full report here and watch highlights below.
The sixth-round of the Challenge Cup welcomes the remaining Super League sides that played in the Super 8s last season including St Helens, Wigan Warriors, Castleford Tigers, Warrington Wolves, Huddersfield Giants, Hull FC, Wakefield Trinity and Catalan Dragons.
Today’s action includes Wigan Warriors’ trip to Warrington Wolves, where the Wire will hope for a repeat of their 23-0 quarter-final victory over the 19-time winners last year, while Huddersfield host St Helens, who haven't made it through to the final at Wembley since 2008 where they beat Hull FC.
The Challenge Cup is a knockout rugby league cup competition held annually since 1896, with the exception of 1915–1919 and 1939–1940. It involves amateur, semi-professional and professional clubs.
The teams from the top tier of rugby league, known as the Super League, enter the Cup in the fifth and sixth rounds, with the final of the prestigious competition held at Wembley Stadium.
The current holders of the Challenge Cup are Catalan Dragons who defeated Warrington Wolves 20–14 to become the first non-British team to win the competition in its 117-year history.
Wigan Warriors are the most successful club in the history of the competition, winning the cup a record 19 times.
The BBC will show games from each round of the Rugby League Challenge Cup live on the BBC Sport website and app and on TV in 2019.
From the sixth round coverage switches from online to BBC One and BBC Two every weekend up to and including the final at Wembley on 24 August.
Our coverage continued yesterday with Super League's Leeds Rhinos travelling to 2003 winners Bradford Bulls of the Championship - you can catch up with that game here. Today's live game sees an all-Super League tie as Warrington Wolves’ host record 19-time winners Wigan Warriors.
Sunday, 12 May
Sixth round: Warrington Wolves v Wigan Warriors plus Red Button Forum
14:05-16:40 BST, BBC One, Connected TV and BBC Sport website and app plus BBC iPlayer
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