Premiership player of the month James Short is one of five Exeter changes from their semi-final victory.
He comes in at wing, while back row Dave Ewers makes his first start in four months after a knee injury and Scotland prop Moray Low also returns.
Leicester recall flanker Mike Williams and wing Peter Betham as they make four changes to the side that beat Saracens.
Harry Thacker and Lachlan McCaffrey are the others to return, with JP Pietersen and captain Tom Youngs on the bench.
Centre Matt Smith, among the Tigers replacements, will make his 200th appearance for the club if he comes on.