Saracens make four changes from the side which narrowly beat Ospreys in the European Champions Cup last weekend.
Scrum-half Ben Spencer and Nick Tompkins return in the back line while prop Vincent Koch and flanker Schalk Burger are named in the pack.
Irish have kept faith with seven players who were part of the 44-7 win at Stade Francais in the European Challenge Cup on Saturday.
Joe Cokanasiga and Tom Fowlie start on the wing and centre respectively.
Saracens: Goode; Williams, Tompkins, Barritt (capt), Wyles; Farrell, Spencer; Vunipola, George, Koch, Isiekwe, Kruis, Clark, Burger, Wray.
Replacements: Tolofua, Barrington, Figallo, Skelton, Earl, Wigglesworth, Lozowski, Earle.
London Irish: Bell; Cokanasiga, Fowlie, Mulchrone, Lewington; Marshall, Meehan; Franks, Paice (capt), Du Plessis, Van der Merwe, Paulo, McNally, Cowan, Treviranus.
Replacements: Woolstencroft, Elrington, Hoskins, Schatz, Northcote-Green, Steele, Brophy Clews, Ojo.