Great Britain’s fourth seed Alfie Hewett’s defeat by Dutchman Tom Egberink was the biggest upset of the British Open second round in Nottingham.
Hewett lost 4-6, 6-3, 6-2 and another high-profile casualty was sixth-seeded Swede Stefan Olsson, beaten 6-2, 3-6, 6-3 by Japan's Takuya Miki.
The top two seeds, top-ranked Gustavo Fernandez of Argentina and second-ranked Shingo Kunieda of Japan, went through without alarms.
Fernandez overcame Japan’s Takashi Sanada 6-2, 6-4 and Kunieda inflicted Britain's second defeat of the round with a 6-3 6-0 win over Dermot Bailey.
In the women's singles, eighth-seeded Briton Lucy Shuker was the only seed to fall in the second-round, losing 6-3, 6-3 to the United States' Dana Mathewson.