Jonathan Rea was ruled out of Sunday's World Superbike races in Misano after crashing during the morning warm-up.
The Castrol Honda rider came off his bike at turn eleven during the 15-minute session and suffered fractures to his right arm and collarbone.
Eugene Laverty finished fifth in race one but had to settle for 13th in race two after running off the track and then rejoining the race.
Laverty now lies fourth in the standings and Rea eighth.
Carlos Checa won both races to extend his lead in the championship.
Max Biaggi was runner-up in both races and is second in the series.
Tom Sykes edged out Laverty for fourth position on the final corner of the opening race.
Rea was taken to the medical centre for checks after the red flags went out to end the warm-up session.
Rea had been due to start the races from 11th place on the grid, with Laverty the 10th fastest qualifier.
"The weekend just went from bad to worse really," said a disappointed Rea.
"I had a crash on Saturday which needed some stitches in my arm and then a 230kph crash on Sunday at one of the fastest corners on the calendar.
"I'm frustrated at the run of bad luck I've had recently and I have some injuries that I want to take time to heal properly.
"I'll have to miss Aragon next week but Brno is a month off and the doictors tell me that the break in my arm would normally keep someone off work for three weeks.
"I'll try to come back for Brno at 100 per cent as it's a circuit that suits me and the bike," added the Ballyclare rider.