Croft motor racing circuit will not host the British Superbikes in 2012, despite being offered a stage by the organisers BSB.
The track is limited to 40 days of activity per year after a High Court injunction in 2009 reacted to noise levels complaints by residents.
"They made a decision that they need to maximise those 40 days use," British Superbikes said on their Facebook page.
A BSB event takes in three days of racing, including qualifying.
"It's disappointing not to have a round in the North East," the statement continued.
"We've always appreciated the great work organisations such as the North Yorkshire Road Racing Supporters Club put into racing.
"The simple fact is that Croft was offered a 2012 round but sadly for them they are working under extremely tough operating conditions, probably the most of any UK circuit, with only 40 operational days use a year."
Motorsport has a strong presence in the North East and Cumbria, particularly in superbikes.
"British Superbikes at Croft is one of the biggest sporting events in the region and not to have it here is a massive blow for fans, teams and officials," motorsport journalist Larry Carter told BBC Look North.
"It's probably like not having the Tyne-Wear derby in football taking place, that's how big it is in motorsport circles.
"Hopefully it is only for this year, from what I understand it's only the one year so hopefully it will be back again in 2013."
BSB has also announced that the Assen circuit in the Netherlands will be added to the calendar in 2012.