Tyrone maintained their unbeaten run in 2012 by soundly beating rivals Derry in the Division Two match at Healy Park.
Derry got the first two points but were then overrun and a goal by the superb Michael Murphy helped Tyrone establish a 1-7 to 0-3 lead by half-time.
Peter Harte gave Derry goalkeeper Paul Morgan no chance with a well-taken penalty in the second half.
Matthew Donnelly, Owen Mulligan and Kyle Coney all registered scores in a one-sided second half.
Tyrone, who won the McKenna Cup on January, and Meath are the only teams with maximum points after two rounds of matches in Division Two of the National Football League.
Derry, along with Kildare and Westmeath, are still seeking their first points of the season.
After Mark Lynch and Charlie Kielt gave Derry an encouraging start, Tyrone hit back with scores by Murphy, Mulligan and Martin Penrose.
Paddy Bradley brought Derry level briefly, but Murphy pointed again before scoring his goal from Penrose's flick.
From then on, it was a one-sided affair and, although Derry were without some injured players, the heavy defeat leaves manager John Brennan with plenty to mull over.