Down will be without injured pair Danny Hughes and Dan Gordon for Sunday's National Football League Division One semi-final against Cork at Croke Park.
Hughes did not feature in Sunday's win over Laois after tearing a hamstring and he is expected to be out of action for at least six weeks.
The Saval clubman would therefore miss the final should Down progress.
Full-back Gordon is also unlikely to play any part in the league campaign after breaking a bone in his foot.
Gordon was replaced by Damien Turley early in the second half of his side's 2-11 to 0-10 win in O'Moore Park.
Both Hughes and Gordon are expected to be fit in time for Down's Ulster SFC opener against Fermanagh on 3 June.
Neill McParland is another player who is doubtful for the Croke Park showdown after he was forced to withdraw in the second half of last weekend's game at Portlaoise.
Mourne manager James McCartan has a number of other injury concerns to contend with as Liam Doyle, Damien Rafferty and Conor Maginn remain sidelined, while Paul McComiskey has yet to feature since returning to the squad last month.
McCartan is still looking for his first win over Cork as Down boss, having lost the 2010 All-Ireland final to the Rebels by a single point and then last year's round four qualifier by 12 points.
The Mournemen finished their regular league campaign by winning three of their last four matches, the only blemish being a narrow defeat away to rivals Armagh.