MacRory Cup holders St Michael's Enniskillen and last year's beaten finalists St Patrick's Maghera have been paired in the draw for the last eight of this season's competition.
Among the other quarter-final ties is a clash between St Patrick's Dungannon and St MacCartan's Monaghan.
St Colman's Newry will face Omagh CBS and Abbey CBS Newry will take on St Paul's Bessbrook.
The precise venues, dates and throw-in times have yet to be finalised.
The matches will take place between 6 and 9 February 2013.
St Michael's recovered from four points down at half-time to win this year's decider against the south Derry school.
Enniskillen manager Dominic Corrigan said his team had been handed a draw "which we certainly didn't want".
"Maghera are certainly one of the top teams in the competition," added Corrigan.
"They will be very keen to avenge last year's final defeat and we know we will have a battle on our hands.
"Our 15 starters from last year are all gone so it's a whole new team. But the boys are working hard and slowly but surely, they are improving."
St Paul Bessbrook's clash with Abbey CBS will see a number of players from both sides in action against club-mates.
Bessbrook are managed by former Armagh player John Rafferty.