Dan Kneen will hope to add to his win in the Tandragee 100 feature event when he takes in this weekend's Cookstown 100 road races on the Orritor circuit.
The Manxman will race in the Superbike and Supersport classes on his Mar-Train Yamahas as he seeks to emulate his big bike success on his debut in 2014.
William Dunlop will be on board his MSS Kawasaki Superstock machine and should also be in the Supersport 600cc races.
Derek Sheils and Malachi Mitchell-Thomas ride for Cookstown BE Racing.
Dunlop suffered clutch problems with his CD Racing 600 Yamaha at Tandragee but will hope to have it repaired in time for the third Irish national road race of the season.
Other leading entries include Mullingar's Derek McGee, Michael Sweeney, Seamus Elliott, Rob Barber, Michael Dokoupil and Conor Behan.
Welshman Rhys Hardisty, Sam Wilson, Neil Kernohan, Davy Morgan, Paul Jordan, Nigel Moore and Adam MacLean wil be expected to feature strongly in the two-stroke races.
Four races are scheduled to take place on Friday night, with the remaining 15 events on the programme scheduled for Saturday.
Roads close on Friday at 12:00 BST and on Saturday at 10:00 BST.