Britain's showjumpers will try to continue the equestrian success story for the home nation in Greenwich, while boxer Nicola Adams and the women's hockey team are each one win from gold medal matches.
Here are Wednesday's events to watch out for (all times BST):
Fresh from their stunning gold-medal team success in a dramatic jump-off against the Netherlands, British trio Brash, Maher and Skelton fight each other and a few dozen other rivals for the individual Olympic title.
- BOXING (13:45-14:00): Nicola Adams, women's flyweight
Leeds flyweight Nicola Adams has been the most successful of Britain's trio as women's boxing makes its Olympic debut. With a bronze medal guaranteed, she takes on Mary Kom for a place in the gold medal match. Kom is one of India's sporting greats as a five-time world champion. Light-welterweight Tom Stalker is Britain's other fighter in action on Wednesday. He is up against Munkh-Erdene Uranchimeg of Mongolia (22:00), with at least a bronze guaranteed for the winner.
- CANOE SPRINT (09:38): Tim Brabants, men's K1
Since winning canoe sprint gold in Beijing, Brabants has gone back to his medical career for two years, returned to canoeing, overcome a shoulder injury that nearly took him out of the sport, and fought off young rival Paul Wycherley for the one place in the team. Brabants only just made it into the K1 1000m final and admits it will be difficult for him to retain his title. Canada's Adam Van Koeverden looks like the man to beat. In the women's K4 500m, Jess Walker, Angela Hannah, Louisa Sawers and Rachel Cawthorn go for Britain (10:44).
Great Britain's women are through to the Olympic semi-finals for the first time since 1996, but they face a tough task against Argentina. 'Las Leonas' are ranked number two in the world and on a mission to finally win Olympic gold for hockey superstar Luciana Aymar. Argentina beat Britain 1-0 in the Champions Trophy final in Rosario earlier this year, so expect this one to be tight.
- ATHLETICS (10:45): Mo Farah, men's 5,000m
Mo Farah begins his quest for a second gold of these Games with the heats of the 5,000m (10:45). The evening session in the Olympic Stadium sees Shara Proctor go in the long jump final (20:05), three British women - including World silver medallist Hannah England - in the 1500m semi-finals (19:45), Usain Bolt try to qualify (20:10) for the men's 200m final and his compatriots aim to continue Jamaica's sprint domination in the women's 200m final (21:00). The men's 110m hurdles final with Britain's Andy Turner, is at 21:15.
- BMX (15:00-15:24): Shanaze Reade
Reade was the favourite going into Beijing four years ago before crashing out, so the 23-year-old is desperate to add Olympic gold to her three world titles. She begins her campaign with the seeding phase. Liam Phillips, who suffered a fractured collarbone in May, goes in the men's event.
Horse Guards Parade will have an American flavour on Wednesday night when 2004 and 2008 Olympic champions Kerri Walsh Jennings and Misty May-Treanor take on compatriots April Ross and Jennifer Kessy in the first beach volleyball final at the iconic venue.