Leeds Rhinos winger Ben Jones-Bishop is likely to be out for four months after suffering a shoulder dislocation.
The 22-year-old, who scored a hat-trick in Leeds' opening day win against Bradford, was injured in the Rhinos' victory over Salford last week.
Rhinos head coach Brian McDermott said the news was a blow for England, as well as the player and his club.
McDermott said: "Ben was performing so well it looked as if we had a very exciting player for the national team."
Jones-Bishop spent last season on loan at Harlequins, but had to undergo shoulder surgery last September.
Leeds have recalled utility back Zak Hardaker from his loan spell at former club Featherstone, and the 19-year-old may make his debut in the home game against St Helens on Saturday.
McDermott backed Hardaker to make an immediate impression.
He said: "Zak has shown a real improvement on and off the field in recent weeks. He has been getting some good game-time with Featherstone and is well used to our systems as he trains the first part of the week with us each week."