Winger Damien Cardace led the way with a hat-trick as Catalan Dragons ran in 12 tries against Sheffield Eagles to reach the Challenge Cup quarter-finals.
The French side ran in five tries before the break to lead 26-0 through Cardace, who got two, Vincent Duport, Leon Pryce and Thomas Bosc.
Cardace, Bosc and Pryce all scored again in the second half, along with Steve Menzies and Cyril Stacul.
Eloi Pelissier then bagged a brace, Eagles replying through Vinny Finigan.
After their narrow win at Hull KR in round four and this thumping of the 1998 Wembley winners, the Catalans remain on course to reach their second final in five years.
This year's Challenge Cup quarter-final draw will take place on Tuesday, 1 May at 0820 BST, BBC Radio Five live.
SATURDAY EVENING'S LINE-UPS
Catalan Dragons: Pryce; Sa, Stacul, Bosc, Dureau; Ferriol, Henderson; Casty, Menzies, Raguin, Pelissier, Gossard, Millard.
Replacements: Simon, Fakir, Paea, Baitieri, Duport, Cardace.
Sheffield: Knowles; Yere, Turner, Morrison, Straughier; Brown, Taulapapa; Brambani, Stringer, Howieson, Finigan, Higgins, Rowe.
Replacements: Hirst, Henderson, Green, Scott, Szostak, Hepworth.