Holders Warrington Wolves face a trip to Championship side Keighley Cougars in the Challenge Cup fourth round.
The Wolves have lifted the trophy at Wembley in three of the last four seasons, beating Leeds 35-18 in last year's final.
Leeds Rhinos face Castleford Tigers and Hull KR host St Helens in the only all-Super League ties of the round.
Featherstone, who shocked the Tigers in last season's fourth round, travel to London Broncos.
Fellow Championship sides Hunslet and Batley face Super League opposition in Catalans and Huddersfield respectively.
The draw has also thrown up a Cumbrian derby, with Whitehaven hosting former winners Workington Town.
All 16 fourth-round ties will be played during the weekend of 20-21 April.
CHALLENGE CUP FOURTH ROUND DRAW
Wigan Warriors v Leigh Centurions
Hemel Stags v Wakefield Trinity Wildcats
Hunslet Hawks v Catalan Dragons
Rochdale Hornets v Bradford
Batley Bulldogs v Huddersfield Giants
Hull FC v North Wales Crusaders
Sheffield Eagles v Dewsbury Rams
London Broncos v Featherstone Rovers
Halifax v Barrow Raiders
Widnes Vikings v Doncaster
Keighley Cougars v Warrington Wolves
Leeds Rhinos v Castleford Tigers
University of Gloucester v Salford City Reds
York City Knights v Toulouse
Whitehaven v Workington
Hull KR v St Helens