Captain Jon Clarke says a home draw against Keighley in the Challenge Cup quarter-finals gives Widnes a superb chance of reaching the last four.
But the experienced hooker has warned the Vikings of complacency against a side eighth in the Championship and the lowest-ranked team left in the event.
"You can come unstuck very easily. This is their cup final," the 35-year-old told BBC Radio Merseyside.
"We'll prepare as meticulously as if we were playing Wigan at Wigan."
Meanwhile, prop Eamon O'Carroll has agreed a new two-year contract with the Vikings.
The 26-year-old joined from Hull FC in June 2012, and although he is currently out with a shoulder injury, the Ireland international remains part of coach Denis Betts' long-term plans.