Unbeaten Championship leaders Leigh Centurions have a home derby date with Super League side Salford Red Devils in the fifth round of the Challenge Cup.
The two top-flight Hull clubs, FC and Kingston Rovers, were drawn away to former winners Sheffield Eagles and Bradford Bulls respectively.
Wakefield Trinity, the fourth Super League side in the draw, were given a home derby with Halifax.
Leigh Miners Rangers, the lowest-ranked side, host York City Knights.
Restructuring of the competition means the final eight Super League clubs do not join the competition until the sixth round.
Ties take place on the weekend of 17-19 April.
Hunslet Hawks v Dewsbury Rams
Leigh Miners Rangers v York City Knights
Bradford Bulls v Hull KR
Sheffield Eagles v Hull FC
Batley Bulldogs v Swinton Lions
North Wales Crusaders v Featherstone Rovers
Wakefield Trinity Wildcats v Halifax
Leigh Centurions v Salford Red Devils