Super League leaders Widnes will face League 1 outfit Rochdale Hornets in the fifth round of the Ladbrokes Challenge Cup.
Denis Betts' high-flying side were one of four top-flight teams to enter the competition at this stage.
Hull KR, who lost in last year's final to Leeds, are at home to Oldham, Wakefield host Sheffield Eagles while Salford Red Devils travel to Hunslet.
The ties will be played on 16 and 17 April.
The remaining eight Super League sides will enter the competition in the next round.
Wakefield Trinity Wildcats v Sheffield Eagles
Hull KR v Oldham Roughyeds
Toulouse Olympique XIII v Leigh Centurions
Rochdale Hornets v Widnes Vikings
Hunslet Hawks v Salford Red Devils
Halifax RLFC v Lock Lane
Batley Bulldogs v Featherstone Rovers
Dewsbury Rams v York City Knights