Coach Sean Holley admits the Ospreys will be the underdogs when they meet Munster in the Magners League play-offs next Saturday.
The Ospreys came from behind to win 12-10 at Aironi to secure their place in the last four thanks to a late James Hook penalty.
Next Saturday they will face a semi-final trip to Munster, the side who finished top of the Magners League.
"We know we can go to Thomond [Park] and win," said Holley.
"It's the fifth time we've played Munster [this season] and it will be a cracking Saturday night.
"I don't suppose Munster will want to play us but it makes for a great one off game.
"We know it will be a full house and we know it's just a one off final for us.
"For us the shackles are off. We've felt a little bit of pressure - we admit that - in the last couple of weeks ... but now our season restarts.""
Holley's side secured their play-off spot with an unconvincing win over Aironi.
The Italian side has led 7-3 at the interval thanks to Danwel Demas' try.
And it was Hook's late penalty, coupled with the Scarlets' win over Cardiff Blues, was just that secured the Ospreys' trip to Munster next Saturday.
"We're disappointed with our display," said Holley. "We're disappointed with our form since the Six Nations really.
"Perhaps we were due a little bit of luck," said Holley, "Things haven't swung our way at times recently.
"You make your own luck. The boys kept fighting until the end and to their credit perhaps in the end we did show a bit of champion spirit. We've dug deep.
"We haven't played very well but we've come out with a win.
"But over the course of 22 games the table doesn't lie and in that respect we probably just about deserve to be in there.
"We're delighted to be there. [I'm] just a little bit disappointed how we've played recently.
"I think we played most of the rugby tonight. We went out to try and win it [and] not [to] lose it.
"We missed some crucial kicks at goal and a drop goal and perhaps [we] showed a little bit of impatience at times in our attack."