Northampton have confirmed the departures of back Bruce Reihana to Bordeaux and fly-half Shane Geraghty to Brive.
Director of rugby Jim Mallinder has also opted to release Regardt Dreyer and Matt Cornwell.
"They have all contributed to the team's development over the past few seasons," said Mallinder.
"A squad is not just about the 23 players who represent the club on match day.
"It is about what happens during the week away from public view, and the positive atmosphere that we have had at Franklin's Gardens is in no small part down to the contributions that every player makes in the changing room and on the training field."
Six-time England cap Geraghty has featured 55 times for Saints and was a 66th-minute replacement for Stephen Myler in Saturday's Heineken Cup final defeat by Leinster.
The 24-year-old hinted at his move to France on Twitter on Sunday, saying: "Its been.. emotional..+somewhat of a rollercoaster ride. au revoir!"
He will be replaced at Saints by Ryan Lamb, who follows in Geraghty's footsteps by moving to Franklin's Gardens from London Irish.
Former New Zealand international Reihana, who can play across the back three, has made 235 appearances for Northampton since arriving from his homeland in 2002.