Lyon 38-10 Ospreys
French Top 14 newcomers Lyon proved too strong for the Ospreys in the Welsh club's opening pre-season encounter at Stade Marius Berthe.
The hosts fielded a strong line-up against the visitors' youthful side.
Home try-scorers included former South Africa scrum-half Ricky Januarie, who had a brief stint with the Ospreys in the 2009-10 season.
Ben John crossed for Scott Johnson's side with Sam Davies converting and Matthew Morgan adding a penalty.