Shane Jennings has been called into the Ireland team to face France as a replacement for David Wallace who has a minor hamstring injury.
Munster flanker Wallace has been left out of Declan Kidney's team as a precaution and is expected to be fit for the 27 August game against England.
Brian O'Driscoll returns after missing the defeats by Scotland and France.
Gordon D'Arcy plays for the first time this season and Keith Earls moves from the centre to left wing.
Sean O'Brien moves to number six, Jamie Heaslip and Paul O'Connell start, and Stephen Ferris is a replacement.
Ferris has not played since suffering a serious knee injury while playing for Ulster in January.
Irish coach Declan Kidney has made a total of 10 changes to the starting line-up which faced France in Bordeaux on Saturday.
Jonathan Sexton and Tomas O'Leary are named as the half-back partnership.
Rob Kearney is not included after suffering a groin injury at the weekend but the Leinster man should be back training by the end of the week.
Tommy Bowe has played a full part in training but also sits out Saturday's game.
Kidney will name his final 30-man squad for the World Cup on Monday.
Ireland team v France: F Jones; A Trimble, B O'Driscoll, G D'Arcy, K Earls; J Sexton, T O'Leary; C Healy, R Best, M Ross; D O'Callaghan, P O'Connell; S O'Brien, S Jennings, J Heaslip.
Replacements: J Flannery, T Court, M McCarthy, S Ferris, E Reddan, R O'Gara, L Fitzgerald.