Edinburgh captain Greg Laidlaw, who signed a new contract this week, moves to stand-off for the visit of Connacht.
Scrum-half Chris Leck makes his debut, with winger Lee Jones replacing Simon Webster and forwards Jack Gilding and Steven Turnbull called up.
Edinburgh coach Michael Bradley has urged his players to convert improved displays into points as he prepares to host his former side.
The Scots are still searching for their first league win this season.
Connacht coach Michael Bradley has made two changes to his starting XV.
Ethienne Reynecke starts at hooker, with Adrian Flavin moving to the bench.
Johnny O'Connor replaces Ray Ofisa at openside, with Ofisa taking the place of TJ Anderson on the bench.
Dylan Rogers replaces Stewart Maguire as the replacement tighthead prop.
Michael Swift will become the first Connacht player to reach 200 caps this weekend.
Bradley's side lost to a last-minute Ospreys score last time out and the Irishman told the club's website: "It's very important that we get a 'W' on the board tomorrow, no matter how we do it."
Edinburgh: T Brown, L Jones, J Thompson, J King, T Visser, G Laidlaw (captain), C Leck, K Traynor, S Lawrie, J Gilding, G Gilchrist, S Turnbull, S Cox, R Grant, D Denton
Replacements: A Kelly, R Hislop, S Knight, E Lozada, S McInally, A Black, G Hunter, M Scott
Connacht: G Duffy, M McCrea, E Griffin, H Fa'afili, T O'Halloran, M Jarvis, F Murphy, R Loughney, E Reynecke, R Ah You, M Swift, M McCarthy, J Muldoon, J O'Connor, G Naoupu
Replacements: A Flavin, B Wilkinson, D Rogers, D Gannon, R Ofisa, P O'Donohoe, N O'Connor, B Tuohy
Referee: Alan Falzone (FIR)
Assistant Referees: James Matthew, Alan Forrest (both SRU)