Northampton Saints will play January's Heineken Cup clash against Munster at Stadium MK.
Chief executive Allan Robson said: "It will be a massive match in January.
"And we want to give as many Saints supporters as possible the opportunity to cheer their team on against one of Europe's best."
Saints were forced to move the two fixtures to Milton Keynes last season because Franklin's Gardens does not meet Heineken Cup regulations that demand knock-out games are played in grounds with a minimum attendance of 15,000.
But this switch, for a Group B game, is solely based on Northampton's desire to enable more supporters to watch the game.
Robson added: "We had two memorable days in Milton Keynes last season. But we also learned plenty of lessons and have gone to great lengths to make sure that we have got it right this time.
"We have made a point of replicating as closely as possible our seating plan into Stadium MK so that season ticket holders are in the same place as they are at Franklin's Gardens.
"And we have also made sure that season ticket holders on the terrace are at the front of the stands along the sides of the pitch so they are as close to the action as they are normally."
The game is set to be played on the weekend of 20 January, but the final date has yet to be confirmed.