Lock Luke Charteris will not be fit to play again until Wales face Australia on Saturday, 3 December at the Millennium Stadium in Cardiff.
Charteris was one of Wales' best World Cup performers but Newport Gwent Dragons say he has a wrist problem that will prevent him playing before Wales tackle the Wallabies.
"When he first got back [from the World Cup] it was a four-to-six-week injury so it quite possibly could be Australia if Wales pick him as his return match," said Dragons coach Darren Edwards.
"It's disappointing for us here at the Dragons that we can't get him out there on the field.
"But that's the nature of rugby."
Wales' 'foreign'-based players could miss the World Cup bronze rematch altogether.
The Dragons kick off their Amlin Challenge Cup campaign at Cavalieri Prato on Saturday.
They then host Perpignan on Thursday, 17 November when James Hook could make his first return to Wales since joining the French club.
The Dragons' last game before Wales take on Australia is against the Scarlets in Llanelli on Friday, 25 November in the Pro12 League
If Wales coach Warren Gatland feels the 28-year-old, 32-times-capped Charteris is not ready for Test action on his return, he may turn to Ospreys' Alun Wyn Jones as replacements.
Ryan Jones would also be in contention along with Cardiff Blues' Bradley Davies to pack down in the second-row.
Wales will be seeking revenge for their 21-18 bronze medal defeat at Eden Park.
The teams also meet three times in June 2012 when Wales tour Australia.