Edinburgh coach Michael Bradley has made 13 changes for the Pro12 meeting with Glasgow at Firhill.
The Scottish rivals drew 23-23 on Boxing Day in the first leg of what also doubles as the 1872 Cup.
Meanwhile, Glasgow winger Rory Lamont will miss out after failing to recover from a head injury.
Medics are happy with his progress after he was stretchered off on Monday but he has not been deemed ready to play this weekend.
For Edinburgh Simon Webster, Alan MacDonald and Phil Godman all return to the front-line alongside Stuart McInally, Tom Brown and Matt Scott.
The return of Jim Thompson and John Houston from injury completes the back-line while Andrew Kelly returns to the front-row between Kyle Traynor and Jack Gilding.
At lock, Esteban Lozada partners Steven Turnbull, while Netani Talei completes the back-row alongside McInally and MacDonald.
""Sunday will be very different to our match at Murrayfield, with the tighter confines of Firhill and the importance of challenging our whole squad ahead of a season defining month, influencing our approach," Bradley said.
"After Glasgow we have a five-day turnaround to an important home match against Ulster before we return to Heineken Cup rugby. The challenge for us as coaches is to get the best out of our squad over the course of this crucial period.
"It speaks volumes for the squad that we're in a position to field another very strong side in our second match against Glasgow, with an opportunity for these players to show they deserve to be part of another huge month for Edinburgh Rugby."
For Glasgow, Colin Shaw takes the place of Lamont, while Sean Lineen has made made six other changes to their starting fifteen.
Jon Welsh replaces Ryan Grant at loose-head prop.
Dougie Hall and Moray Low form an all-new front row with Welsh, Ryan Wilson starts at No.8, and Chris Fusaro occupies the openside flanker berth with John Barclay moving to the bench.
In the backs, Peter Murchie replaces Troy Nathan and will start at full-back, with Stuart Hogg moving to outside centre.
Coach Sean Lineen commented: "We've freshened things up in the forwards, bringing in guys who have performed well as replacements in recent weeks and have really put their hand up for a start.
"Moray and Dougie bring excellent experience and class to our pack, while Chris Fusaro has been very consistent all season.
"It's great for quality players like John Barclay to have that level of competition, and having his game knowledge and ability to call on from the bench is a real asset for us this weekend.
"We sustained a couple of injuries in the first game, so we've had to shuffle things a bit, but we're more than happy with the quality of the replacements that are coming into the side.
"Sunday is about us coming sharply out of the blocks, hitting the ground running and playing the game on our terms. It's going to be another massively physical battle, so we'll need to be right at the top of our game if we're going to keep hold of the silverware."
Glasgow: Peter Murchie, David Lemi, Stuart Hogg, Graeme Morrison, Colin Shaw, Duncan Weir, Chris Cusiter, Jon Welsh, Dougie Hall, Moray Low, Richie Gray, Al Kellock (captain), Rob Harley, Chris Fusaro, Ryan Wilson. Replacements: Pat MacArthur, Mike Cusack, Ed Kalman, Tom Ryder, John Barclay, Henry Pyrgos, Troy Nathan, Ruaridh Jackson
Edinburgh: Jim Thompson, Simon Webster, Matt Scott, John Houston, Tom Brown, Phil Godman (captain), Chris Leck, Kyle Traynor, Andrew Kelly, Jack Gilding, Steven Turnbull, Esteban Lozada, Stuart McInally, Alan MacDonald, Netani Talei. Replacements: Alun Walker, Robin Hislop, Lewis Niven, Grant Gilchrist, Ross Rennie, Mike Blair, Harry Leonard, Lee Jones.