Sale recorded their highest ever score on the road to humble lowly Spanish side Rugby Club La Vila in pool five of the European Challenge Cup.
Tries by Tom Brady, Joaquin Tuculet and Joe Ward put Sharks on their way before Tim Evans' converted try made it 17-10.
Rob Miller and Richie Vernon tries then stretched Sale's lead up to half time.
Tries by Will Cliff, Scott Mathie, Jordan Davies added their names to the scoresheet along with one more each from Brady, Miller and Vernon.
CR La Vila: Ramirez, Carrion, Knight, Reid, Poggi,McCashian, Quirelli, Martinez Sanchez, Phipps, Hutchinson, Cleary, Walker-Sitton, Els, Gonzalez, Cook.
Replacements: Fusta, Vazquez, Previtera, Davies, Manzano, Hebrard, Evans, Quiramte.
Sale: Tuculet, Brady, Burrell, Davies, Addison, Miller, Mathie, Imiolek, Ward, Cobilas, Ostrikov, Myall, Easter, Taylor, Vernon.
Replacements: Cliff for Addison (41), Fowles for Miller (68), Seymour for Ward (56), Buckley for Cobilas (52), Harrison for Ostrikov (68), Lewaravu for Myall (52).
Ref: Andrew McMenemy (RFU).