Stade Francais ended Worcester's hopes in the Amlin Challenge Cup after a convincing victory saw them book a quarter-final spot as Pool 1 winners.
The unbeaten hosts scored through Paul Warwick, Sergio Parisse and Morgan Turinui to post a 21-3 half-time lead.
Andy Goode scored a solo try for the Warriors but ex-Wasps wing Paul Sackey and Kiwi Byron Kelleher sealed the win.
Worcester had a chance to top the group but ended up suffering their heaviest defeat in Europe for seven years.
Stade Francais: Warwick, Sackey, Turinui, Williams, Arias, Plisson, Dupuy, Milloud, Szarzewski, Attoub, Palmer, Pape, Chollon, Lyons, Parisse.
Replacements: Camara for Sackey (67), Kelleher for Plisson (61), Danty for Dupuy (61), S Wright for Milloud (52), de Malmanche for Szarzewski (52), Roncero for Attoub (52), Mostert for Palmer (41), Rabadan for Chollon (73).
Sin Bin: Pape (71).
Worcester: Classens, Garvey, Grove, Rasmussen, Drauniniu, Goode, Perry, Mullan, Shervington, Taumoepeau, Percival, C Jones, Betty, Abbott, Kvesic.
Replacements: Frost for Classens (61), Carlisle for Rasmussen (56), Pennell for Perry (61), Porter for Mullan (56), Gulliver for Shervington (52), Currie for Taumoepeau (67), Gillies for Percival (56), Lutui for C Jones (52).
Sin Bin: Grove (71).
Ref: Leighton Hodges (RFU).