France Women went over for five unanswered tries as they overwelmed their Welsh Six Nations counterparts at Pandy Park, Cross Keys.
Hooker Gaëlle Mignot was driven over for the first and Audrey Foralani the second as France went into a 12-0 lead at the break.
Mignot added a second, followed by Caroline Ladagnous and wing Elodie Portaires scored their fifth.
Wales' third tournament defeat left them fourth in the final table.
France had a player sin-binned in each half - Marie-Charlotte Hebel in the 35th minute and Sandrine Agricole in the second.
Wales' Sian Williams was also yellow-carded late on to leave them with 14 players at the end.
Wales Women: Rosie Fletcher; Caryl James, Elen Evans, Naomi Thomas, Phillippa Tuttiett; Mared Evans, Laura Prosser; Jenny Davies, Rhian Bowden (capt), Lowri Harries, Vicky Owens, Shona Powell-Hughes, Lisa Newton, Sioned Harries, Jamie Kift.
Replacements: Caryl Thomas, Megan York, Clare Flowers, Sian Williams, Charlie Murray, Rebecca De Filippo, Aimee Young.
France Women: Jessy Tremouliere; Laurelin Fourcade, Elodie Poublan, Majorie Mayans Caroline Ladagnous; Aurelie Bailon, Marie-Alice Yahe (capt); Helene Ezanno, Gaëlle Mignot, Christell Chobet, Marine de Nadaï, Cyrielle Bouisset, Coumba Diallo, Marie-Charlotee Hebel, Audrey Forlani.
Replacements: Laëtitia Salles, Elodie Portaries, Safi N'diaye, Koumiba Djossouvi, Sandrine Agricole, Laura Delas, Jennifer Troncy.