Ospreys fly-half Dan Biggar and four uncapped players have been named in Wales caretaker coach Rob Howley's 38-man squad for their four June Tests.
Uncapped Scarlets full-back Liam Williams, prop Rhodri Jones, Ospreys centre Ashley Beck and Cardiff Blues wing Harry Robinson make the squad.
Wales face the Barbarians on 2 June before three Tests against Australia and a clash against ACT Brumbies.
Injuries rule out centre Jamie Roberts and hooker Huw Bennett.
Fifteen of the squad will miss the Baa-Baas game at the Millennium Stadium to fly to Australia early to acclimatise for the first Test on 9 June.
And because Clermont Auvergne could be in the French Top 14 final that day, their Welsh full-back Lee Byrne is under consideration only for tour standby duty.
Ospreys Lock Ian Evans will miss the first Test against the Wallabies because he is getting married, but will be available for the second and third Tests.
Captain Sam Warburton is set to be part of the early party going to Australia.
Martyn Williams is expected to win his 100th Wales cap coming off the bench against the Barbarians.
Along with Warburton, open-side Justin Tipuric will be part of the advance party to Australia.
The likelihood is Scarlets' Aaron Shingler, who made an impressive Wales debut in the Six Nations against Scotland, will start at seven against the Baa-Baas, with Williams on the bench.
Biggar has impressed recently, not least with his 25-point performance in the Ospreys' 45-10 victory over Munster to reach the Pro12 League final against Leinster.
The 22-year-old won the last of his nine caps against Australia in December, 2011's post-World Cup clash in Cardiff having seen Rhys Priestland overtake him in the Welsh pecking order.
But with Scarlet Stephen Jones' Test career seemingly over, Biggar has an opportunity to re-establish his Test credentials.
The main injury concerns for Howley have been Scarlets hooker Matthew Rees, who has an ankle problem and the midfield options because of Roberts' knee injury.
Scarlets centre Jonathan Davies has been named after recovering from a hernia injury since the start of April, while Scarlet Scott Williams (shoulder) has been included despite struggling recently.
Ospreys centre Andrew Bishop is another to earn a recall, along with Scarlets back-five forward Josh Turnbull, former Newport Gwent Dragons wing Aled Brew and his ex-team-mate wing Will Harries.
Having been an unused and uncapped member of Wales' Six Nations squad, Beck has a chance to press his long-term midfield claims.
The Barbarians match will be Wales' first since they completed the Six Nations Grand Slam against France in March.
Shane Williams is set to line up for the Barbarians against Wales in what will be his and Martyn Williams' final farewell before they retire from top-flight rugby.
Wasps-bound fly-half Jones, 34, is also preparing to face Wales for the invitation club having made a record 104 appearances for his country.
Howley was appointed caretaker coach for the summer after Warren Gatland, the Wales head coach, was ruled out after he fractured both his heels in a fall in his native New Zealand.
Wales squad for June Tests:
FORWARDS: Ryan Bevington (Ospreys), Luke Charteris (Newport Gwent Dragons), Ian Evans (Ospreys), Bradley Davies (Cardiff Blues), Toby Faletau (Newport Gwent Dragons), Rhys Gill (Saracens), Richard Hibbard (Ospreys), Paul James (Ospreys), Gethin Jenkins (Cardiff Blues), Adam Jones (Ospreys), Alun Wyn Jones (Ospreys), Rhodri Jones (Scarlets), Ryan Jones (Ospreys), Dan Lydiate (Newport Gwent Dragons), Ken Owens (Scarlets), Matthew Rees (Scarlets), Aaron Shingler (Scarlets), Justin Tipuric (Ospreys), Josh Turnbull (Scarlets), Sam Warburton (Cardiff Blues), Martyn Williams (Cardiff Blues).
BACKS: Ashley Beck (Ospreys), Dan Biggar (Ospreys), Andrew Bishop (Ospreys), Aled Brew (Biarritz), Alex Cuthbert (Cardiff Blues), Jonathan Davies (Scarlets), Leigh Halfpenny (Cardiff Blues), Will Harries (Newport Gwent Dragons), James Hook (Ospreys), George North (Scarlets), Mike Phillips (Bayonne), Rhys Priestland (Scarlets), Harry Robinson (Cardiff Blues), Rhys Webb (Ospreys), Lloyd Williams (Cardiff Blues), Scott Williams (Scarlets), Liam Williams (Scarlets).