Jersey will host Championship play-off final runners-up Cornish Pirates in the opening game of their debut season in the division.
The game will be played in St Peter at 15:00 BST on Saturday, 1 September.
The return fixture will close the regular season on the weekend of 20 April 2013 in Penzance.
Jersey are scheduled to play two home pre-season friendlies, against Leicester Tigers on 11 August and Loughborough Students on 25 August.
As part of their promotion to English rugby's second tier, they will also feature in next season's British and Irish Cup, although those fixtures will not be confirmed until a later date.