Newport Gwent Dragons have been drawn against London Wasps in the Amlin Dhallenge Cup draw.
The Welsh region have also joined in Pool 3 by French club Bayonne and Rugby Mogliano from Italy.
The Dragons will be hoping to go better than their three wins and three losses in last year's pool stage.
London Welsh will replace Newcastle in the draw if they win their appeal to the Rugby Football Union over reaching Avia Premiership criteria.
Amlin Challenge Cup 2012/13 Pools
Pool 1: Gloucester Rugby, London Irish, Bordeaux-Bègles, Mont-de-Marsan
Pool 2: Perpignan, Worcester Warriors, Femi-CZ VEA Rovigo, Bizkaia Gernika RT
Pool 3: London Wasps, Newport Gwent Dragons, Bayonne, Rugby Mogliano
Pool 4: Bath Rugby, Cammi Rugby Calvisano, Agen, Bucharest Wolves
Pool 5: Stade Français Paris, Newcastle Falcons/London Welsh, I Cavalieri Prato, Grenoble
Amlin Challenge Cup Dates
Round 1: 11/12/13/14 October 2012
Round 2: 18/19/20/21 October 2012
Round 3: 6/7/8/9 December 2012
Round 4: 13/14/15/16 December 2012
Round 5: 10/11/12/13 January 2013
Round 6: 17/18/19/20 January 2013
Quarter-finals: 4/5/6/7 April 2013
Semi-finals: 25/26/27/28 April 2013
Amlin Challenge Cup final: RDS, Dublin (Friday, 17 May 2013, 20:00 BST)