Bedford full-back Jame Pritchard scored 25 points against Plymouth Albion to bring his former side's excellent start to the season to a juddering halt.
James Stephenson, Josh Bassett, Pritchard and Gregor Gillanders all crossed before the break to give the Blues a commanding 29-3 half-time lead.
Albion get an early second half try through Sam Hocking, but that was quickly cancelled out by Henry Staff.
Hooker Jon Vickers scored a second, but Bedford then turned on the gas again.
Ben Ranson, Jake Sharp and Pritchard, who also kicked six conversions and a penalty, completed the scoring.
Albion had started brightly, Paul Roberts missing a couple of early penalties.
But, despite Roberts getting his range in the end with a penalty to add to his two conversions, they were well beaten.
Albion stay third, but now trail second-placed Bedford by nine points.
Bedford: Pritchard; Stephenson, Burke, Staff, Bassett; Atkinson, Baldwin; Fearn, Cochrane, Boulton, Howard, Rae, Gillanders, Harding, Tupai.
Replacements: Seal, Cooper, Armes, Fox, Veenendaal, Sharp, Ransom.
Plymouth Albion: Slade; Bailey, Howley-Berridge, Armitage, Warner; Roberts, Cushion; L Cowan-Dickie, Vickers, Fairbrother, Beukeboon, Ashcroft-Leigh, Sprangle, Hocking, Stephen.
Replacements: McAtee, Morton, Nasiga, Andrew, Salter, Carpenter, Fisilau.
Referee: Tim Wigglesworth (RFU).