Wasps made it two wins from two in Amlin Challenge Cup pool three with a comfortable win in Italy at Mogliano.
The English side took a 21-0 lead thanks to tries from Rhys Thomas, Jonathan Poff and Hugo Southwell before Federico Maso crossed for Mogliano.
Christian Wade and Andrea Masi made it 35-5 at half-time.
Ashley Johnson and Mogliano's Ezio Galon swapped tries before Wade, Tim Payne and Joe Launchbury increased the lead for the visitors.
Mogliano: V Candiago; Onori, E Ceccato, Cerioni, Galon; Padovani, Lucchese ; A Ceccato, Gianesini, Allori, Maso, Pavanello, E Candiago, Swanepoel, Gilbert.
Replacements: Costa Repetto, Meggetto, Naka, Corbanese, Guarducci, Benvenuti, Gazzola, Giabardo.
Wasps: Southwell; Wallace, Daly, Masi, Wade; T Bell, Davies; Payne, T Thomas, Staibano, Palmer, Cannon, Haskell, Poff, Johnson.
Replacements: Lindsay, Swainston, Taulafo, Launchbury, S Jones, Holmes, L Thomas, C Bell.
Referee: David Wilkinson (Ireland).