England have called up Worcester loose-head prop Matt Mullan for the autumn internationals as cover for Joe Marler who is a doubt with a tight hamstring.
London Irish hooker David Paice and Harlequins lock George Robson were called up on Sunday for Northampton pair Dylan Hartley and Courtney Lawes.
Hartley and Lawes suffered knee injuries in Saints' defeat by Saracens.
Quins' Chris Robshaw and London Irish's Jonathan Joseph were also injured in their sides' clash on Sunday.
Flanker Robshaw suffered a nasty eye injury and centre Joseph was forced off with an injured ankle.
On Hartley and Lawes, Saints director of rugby Jim Mallinder said: "They've done something, but we will know a lot more later.
"They are the sort of characters that if they had just got a knock they wouldn't have come off."
The pair are due to have scans on their injured knees on Monday evening.
Lock Lawes had a long lay-off last season because of an injury to his right knee but this time the problem was with his left knee.
Hartley's injury in particular is a headache for England head coach Stuart Lancaster, with Bath's Rob Webber and Harlequins' Joe Gray currently injured and another Bath hooker, Lee Mears, retired from international rugby.
The only other hooker in the senior squad is Leicester's Tom Youngs.
England play Fiji, Australia, South Africa and New Zealand, starting with Fiji at Twickenham on 10 November.