Redruth suffered their second heavy defeat at Hartpury College in as many years as they went down 47-15.
Despite early tries from Paul Thirlby and Owen Hambly giving Redruth a 12-3 lead, Hartpury soon took control.
Alex O'Meara and Alexander Dancer tries put Hartpury in front after 20 minutes as they led 16-12 at the break.
But two tries from Ross Moriarty and one each for Billy Burns and Brandon Walker, along with 15 points from the boot of Burns sealed the win.
Redruth had suffered a 40-10 loss in National Two South at Hartbury College last season.