Newport Gwent Dragons scored eight tries as they completed a comprehensive double over Italy's Mogliano.
The hosts won 33-0 in the previous weekend's encounter.
And Mogliano fared little better as Dan Evans, Mike Poole and Wayne Evans crossed in an opening period in which the irresistible hosts were also awarded a penalty try.
Pat Leach, Jonathan Evans, Phil Price and Jack Dixon crossed after the break to register the bonus-point win.
Newport Gwent Dragons: Hallam Amos; Tonderai Chavhanga, Pat Leach, Ashley Smith, Mike Poole; Dan Evans, Jonathan Evans; Owen Evans, Sam Parry, Dan Way, Andrew Coombs, Rob Sidoli, Tom Brown, Lewis Evans (capt), Ieuan Jones.
Replacements: Hugh Gustafson, Phil Price, Nathan Buck, Adam Jones, Toby Faletau, Wayne Evans, Lewis Robling, Jack Dixon.
Rugby Mogliano: Vittorio Candiago; Filippo Guarducci, Enrico Ceccato, Tommaso Boni, Ezio Galon; Edoardo Padovani, Enrico Endrizzi; Agustin Costa Repetto, Ivan Gianesini, Masamiliano Ravalle, Federico Maso, Enrico Pavanello, Marco Barbini, Andrea Ceccato (capt), Meyer Swanepoel.
Replacements: Nicola Corbanese, Laert Naka, Gianluca Ceneda, Jacopo Bocchi, Amedeo Di Pietro, Alberto Lucchese, Giovanni Benvenuti, Antonio Giabardo.
Referee: David Wilkinson (Ire).
Assistant referee: Eddie Hogan-O'Connell (Ire), Darragh McCormack (Ire).
TMO: Alan Rogan (Ire).
Citing commissioner: Richard McGhee (Sco).