Worcester ran in 12 tries as they kept alive their slim Challenge Cup qualification hopes with a crushing win at Pool Two strugglers Rovigo.
Tries from Nikki Walker, Danny Gray and two scores from Josh Drauniniu put the visitors in control.
And despite a brief home fightback before the break, Worcester eased to victory, with eight further tries.
Replacement centre Max Stelling crossed twice, while Drauniniu completed his hat-trick seconds before the end.
Jake Abbott, Andy Short, Blair Cowan and Neil Best also scored tries, while Gray added a total of 10 conversions for a 24-point individual haul.
Despite the huge win, Worcester's hopes of qualifying remain slim as Perpignan edge the head-to-head record in the two meetings between the teams, as a result of tries scored.
If next weekend's concluding fixtures go according to form, the French side will qualify as group winners.
VIEW FROM THE DRESSING ROOM
Warriors assistant head coach Nigel Redman told BBC Hereford and Worcester:
"We scored 80 points and managed to get our replacements on as well, including some of the younger lads like Ben Howard and Max Stelling, and they all gave a good account of themselves.
"Obviously, Perpignan have to play Rovigo in their last game of the season.
"All we have got to do now is to make sure we are up for it next week when we play Guernica at home.
"We have to do our part, which is to beat them, score four tries and get as many points as we can."
Rovigo: Basson; A Zorzi, Menon, van Niekerk, Bacchetti; Lenarduzzi, Zanirato; Quaglio, Mahoney, Cegile, Tumiati, Montauriol, Persico, Ciochina, Ferro.
Replacements: Lombardi for Cegile (51), P Gobbo for Bacchetti (61), Calabrese for Zanirato (55), Anouer for Ferro (55), C Gaeta for Quaglio (69), Maran for Mahoney (69).
Not Used: Duca.
Worcester: Classens; Walker, Clarke, Short, Drauniniu; Gray, Arr; Mullan, Hayes, Schofield, O'Donnell, Gillies, Betty, Abbott, Cowan, Currie.
Replacements: Howard for Classens (56), Stelling for Clarke (56), Frost for Arr (58), Currie for Mullan (58), Best for Abbott (65), Lutui for Gray (65), Andress for Currie (69).
Not Used: Percival.
Referee: Dudley Phillips (RFU).