Argentina have made four changes to the side which was beaten by England to face Wales in Cardiff.
Santiago Cordero will be handed his second cap for the Pumas in place of Juan Imhoff on the wing.
While there are also call ups for lock Manuel Carizza, scrum-half Martin Landajo and full-back Joaquin Tuculet into the starting line-up.
Gabriel Ascarate and Tomas Lavanini join Worcester Warriors' Leonardo Senatore as the new faces on the bench.
Carizza comes in at lock for Mariano Galarza, who has returned to Worcester in an agreement between Argentina and the English club for the release of back row forward Senatore.
Argentina will be looking to avoid their eighth successive defeat, which will equal the record for their worst losing run in history.
Coach Daniel Hourcade will be looking for a response from his team following the 31-12 defeat to England at Twickenham.
Argentina will be looking to repeat their victory over Wales during their last European tour a year ago, when the Pumas won 26-12.
Argentina: Joaquin Tuculet, Horacio Agulla, Marcelo Bosch, Santiago Fernandez, Santiago Cordero, Nicolas Sanchez, Martin Landajo; Marcos Ayerza, Eusebio Guinazu, Maximiliano Bustos, Manuel Carizza, Patricio Albacete, Pablo Matera, Julio Farias Cabello, Juan Manuel Leguizamon (captain)
Replacements: Santiago Iglesias, Nahuel Lobo, Matias Diaz, Tomas Lavanini, Leonardo Senatore, Tomas Cubelli, Gabriel Azcarate, Lucas Gonzalez Amorosino