Fly-half Dan Carter and prop Tony Woodcock are ruled out of New Zealand's Test against Ireland after picking up injuries in the 30-22 win over England.
Carter's 100th Test appearance was cut short when he limped off with an Achilles injury in the first half of Saturday's game at Twickenham.
Fellow centurion Woodcock did not emerge for the second half after hurting his hamstring before the break.
Coach Steve Hansen said on Monday that the pair would return to New Zealand.
The remainder of the All Blacks squad will prepare for the Ireland Test, in which they will bid to become the first international team in rugby's professional era to win every match of the season.
"Dan has not had a scan yet, but (team medics) said with the problems he's been having it's just too big a risk to go through the week," said Hansen on the All Blacks' official website.
"We've got Crudes (Aaron Cruden) and Beauden (Barrett) who can both do the job, so we'll just get on with it with those two."
The Achilles problem brought Carter's season to an anti-climactic end.
He was already scheduled to take an extended break from the game after the Ireland Test to try to ensure he is fit for the 2015 World Cup.
Carter, 31, will sit out England's three-Test tour to New Zealand in June next year and most of the 2014 Super Rugby season in a bid to be fit for international rugby's showcase event.
Carter, widely regarded as the best player ever in his position, has been plagued by injuries for years, rupturing an Achilles playing club rugby in France and missing much of New Zealand's triumphant 2011 World Cup campaign with a groin strain.
The problems have intensified in the last 18 months, but his country's hot streak of form shows no sign of abating.