Bath fly-half George Ford is in line to make his England debut in Saturday's key Six Nations match against Ireland at Twickenham.
The 20-year-old has been named in the squad as cover for Owen Farrell.
England head coach Stuart Lancaster said: "We feel that the time is right to include George Ford in the squad.
"We have successfully integrated many young players over the last two years. George is the next exciting talent to make his mark in the senior squad."
As expected, Bath tight-head David Wilson replaces injured prop Dan Cole. The XV to face Ireland at Twickenham will be confirmed on Thursday.
Ford, son of former Great Britain rugby league international and current Bath coach Mike Ford, began his career at Leicester, becoming the youngest union player to make his professional debut when he appeared in a cup match aged only 16 years 237 days.
He spent four years with the Tigers before joining Bath last year, and has represented England at U18, U20 and Saxons level.
Ford was brought into the England Elite Player Squad in January, as a replacement for the France-bound Toby Flood.
He was not included in the match-day squad of 23 for England's first two Six Nations matches, but did travel to Paris on the opening weekend as a non-playing reserve.
Ford's father Mike said he was delighted at the prospect of his son representing England.
"He's had a lot of boxes to tick, a lot of hoops to jump through to get where he is, and he has done that remarkably well. If it is his time this Saturday, then I think he fully deserves it," he said.
Forwards: David Attwood (Bath Rugby); Dylan Hartley (Northampton Saints); Joe Launchbury (London Wasps); Courtney Lawes (Northampton Saints); Joe Marler (Harlequins); Ben Morgan (Gloucester Rugby); Chris Robshaw (Harlequins); Henry Thomas (Sale Sharks); Billy Vunipola (Saracens); Mako Vunipola (Saracens); David Wilson (Bath Rugby); Tom Wood (Northampton Saints); Tom Youngs (Leicester Tigers);
Backs: Mike Brown (Harlequins); Luther Burrell (Northampton Saints); Danny Care (Harlequins); Lee Dickson (Northampton Saints); Owen Farrell (Saracens); George Ford (Bath Rugby); Alex Goode (Saracens); Jonny May (Gloucester Rugby); Jack Nowell (Exeter Chiefs); Billy Twelvetrees (Gloucester Rugby)