Ospreys say their Wales players are desperate to play in Saturday's European Champions Cup match at home to Racing Metro.
Dan Biggar, Alun Wyn Jones, Rhys Webb and Scott Baldwin all played 80 minutes as Wales beat South Africa 12-6.
But despite their gruelling autumn, Ospreys backs coach Gruff Rees says their Test players are eager to play.
"They're some of the toughest young men I know with a real passion for what we do here," he said.
Cardiff Blues have decided to rest Wales captain Sam Warburton for their European Challenge Cup match with London Irish on Saturday as a precaution after he sustained a slight shoulder injury during the win over the Springboks.
Although all four of Ospreys' Welsh international contingent played the entire match against South Africa, Rees says they are ready for a regional return.
"If anyone can, those guys can," he added.
"They're in a good mental state. They've all been in good form and come back off a good win.
"Physically, they're having to be nursed through the first couple of training days. They're doing the absolute minimum.
"It's not ideal but that's the state of play with the fourth international."
Biggar had a particularly bruising encounter against the Springboks, making 11 tackles during his man-of-the-match display.
"I'm not going to lie. You see him throwing himself in there and your first reaction is 'be careful, Dan'," said Rees.
"But it's part of his armoury. For me, that's what makes him the bravest, gutsiest number 10 in the world game."
Ospreys are currently third in Pool 5 of the European Champions Cup, having won one and lost one of their two matches to date.
Victory on Saturday could see them overtake Racing Metro at the top of the table, and Rees believes their returning internationals could give them a vital lift.
"They're buoyant about what they achieved but they move on really quickly," he said.
"Their experience is invaluable and it's a big game for us. They want to be a part of it."