|RBS Six Nations: Italy v Wales|
|Venue: Olympic Stadium, Rome Date: Saturday, 21 March Kick-off: 12:30 GMT Coverage: Live on BBC TV, HD, Red Button, BBC Radio Wales, Radio Cymru Radio 5 live, 5 live sports extra, online, mobile, the BBC Sport app and Connected TV|
Wales head coach Warren Gatland says the fact England are in action last on Saturday puts them in the "box seat" to win the Six Nations title.
Gatland's side are in action first against Italy in Rome at 12:30 GMT.
They need a big win to overhaul their inferior points-difference compared with title rivals Ireland and England.
"England are definitely going to know what they need to do to win the Championship, so that puts them in the box seat," said Gatland.
"But it's not going to be easy if you need 15 or 20 points to have to beat France by, and they are a tough team to put away."
England, Ireland and Wales are all on six points with three wins, and England's points difference of 37 puts them top, ahead of Ireland's 33 and Wales' 12.
Gatland says Wales can put pressure on Ireland and England, but must focus on winning their match first and not chasing points.
"For us, it's about making sure our focus is on ourselves," he said. "It's going to be tough on Italy. They have a six-day turnaround.
"Our focus is to win the game first and build a lead and then maybe we can play some good rugby.
"We need to keep the ball in hand very much like we did against Ireland.
"If we do create chances, finish them off and fingers crossed we can do that, then it puts a little bit of pressure back on Ireland and England for the rest of the afternoon."
Wales skills coach Neil Jenkins said: "I am sure we will be kicking ourselves if we didn't win and the other games went Scotland's way and France's way.
"The main objective is to win the game, and see where that takes us.
"England will know what they have to do when they play last on Saturday, but no matter what time you play, the focus is still the same for us."
Wales wing Liam Williams says he and his team-mates can approach the task without any pressure because of the staggered kick-off times.
"There is no pressure on us. We are on first to play, we will go out there, do the business and then sit back and watch the other matches," said the Scarlets player.
"It would be huge [to win the title] for Wales, heading towards the World Cup. But we know a lot of things need to happen for that to come to pass.
"All we can do is try to do our bit against Italy, and then keep our fingers crossed."
Hooker Leonardo Ghiraldini has taken over from injured Italy captain and star number eight Sergio Parisse and says they must maintain self-belief in Parisse's absence.
"Sergio is one of the best number eights in the world," said Ghiraldini.
"Of course he's a big loss for us, but at the same time, it's an opportunity for others to take responsibility.
"Sergio could play in every national team in the world, but we have to keep believing."