Relegated London Welsh will play beaten play-off finalists Bristol in their second game in the Championship.
Welsh have a trip to Doncaster in their first game back in English rugby's second tier before hosting Bristol in their first game at the Kassam Stadium.
The Exiles lost every one of their 22 matches in the top flight last season.
Bristol's first game since losing to Worcester in the play-off final is at home to Bedford Blues, while newly promoted Ealing open at Rotherham.
Nottingham have their longest mainland away trip of the season on the opening weekend as they travel to Penzance to play Cornish Pirates, Jersey must fly to Leeds to face Yorkshire Carnegie and last season's second-from-bottom side Moseley go to play-off semi-finalists London Scottish.
The first round of fixtures will be played between Friday 4 and Sunday 6 September.
"There are some fascinating clashes in the opening round and beyond and I for one am eager to see how the season unfolds," said Championship clubs chairman Geoff Irvine.
"If we learned anything from last season, it's that anything can happen in this league and that will make for some pretty engaging and exciting rugby to come."
|Opening Championship fixtures|
|London Scottish v Moseley|
|Bristol Rugby v Bedford Blues|
|Doncaster Knights v London Welsh|
|Cornish Pirates v Nottingham Rugby|
|Yorkshire Carnegie v Jersey|
|Rotherham Titans v Ealing Trailfinders|