Ireland coach Tom Tierney has named six new caps in his starting side for Saturday's game against England at Twickenham Stoop (15:00 GMT kick-off).
Jeamie Deacon, Mairead Coyne and Aine Donnelly are the backs debutants in a game which will be Ireland women's first-ever autumn international.
Hooker Cliodhna Moloney will earn her first cap with Elaine Anthony and Ciara Cooney named in the second row.
The replacements include uncapped Ulster player Claire McLaughlin.
Tierney said the team's first autumn international would be "another step in the development in women's rugby".
"We have an opportunity to have a look at some new players and combinations building towards the Six Nations," he added.
Ireland will be defending the women's Six Nations title next spring.
Ireland: Niamh Briggs (Munster), capt; Jeamie Deacon (Leinster), Aine Donnelly (Leinster), Jackie Shiels (Richmond), Mairead Coyne (Connacht); Sene Naoupu (Connacht), Larissa Muldoon (Skewen); Ruth O'Reilly (Connacht), Cliodhna Moloney (Leinster), Ailis Egan (Leinster); Elaine Anthony (Munster), Ciara Cooney (Connacht); Sophie Spence (Leinster), Paula Fitzpatrick (Toulouse), Heather O'Brien (Toulouse).
Replacements: Zoe Grattage (Munster), Fiona Reidy (Munster), Fiona O'Brien (Leinster), Katie Norris (Leinster), Lindsay Peat (Leinster), Mary Healy (Connacht), Nora Stapleton (Leinster), Claire McLaughlin (Ulster)