Sale captain Dan Braid will be out for 12 weeks as he requires surgery for a shoulder injury suffered in their Premiership win over Wasps.
Former All Blacks flanker Braid has made 65 appearances for Sharks since joining from Auckland Blues in 2013.
The 34-year-old has featured in all eight of Sale's Premiership games this season, scoring one try.
Braid will be retiring from playing at the end of the season to take up a coaching role with the club.
Sharks are currently eighth in the Premiership table, 12 points outside the top four.