|Wasps (21) 38|
|Tries: Young, Piutau, Wade, Robson, Bassett, Johnson Cons: Gopperth Pens: Jackson 2|
|London Irish (7) 12|
|Tries: Williams, Lewington Cons: Pens: Brophy-Clews|
|Relive the final day of the Premiership season|
Wasps ran in six tries to thrash relegated London Irish, but victory was not enough to earn them a home semi-final in the Premiership play-offs.
Irish, condemned to life in the second tier before kick-off, momentarily led through Johnny Williams' try after Ruaridh Jackson landed two Wasps kicks.
Wasps led 21-7 at the break, with Christian Wade among the try scorers.
Despite going on to ease to victory, Exeter's win at Harlequins ensured they will host Wasps in the last four.
The Chiefs' resounding 62-24 triumph at The Twickenham Stoop means Dai Young's Wasps travel to Sandy Park on Saturday, 21 May. For Wasps to finish above Exeter, they were relying on Quins beating the Chiefs.
|Premiership play-off semi-final line-up|
|Saracens v Leicester (Saturday, 21 May - 12:30 BST)|
|Exeter v Wasps (Saturday, 21 May - 15:15 BST)|
Early on the hosts played it safe with two penalties from Jackson, but Williams' try for Irish added a sense of urgency to the occasion.
Thomas Young then went over to restore Wasps' lead and Charles Piutau added a second try before the visitors had Ofisa Treviranus sin-binned. Wasps made the one-man advantage count, with Wade crossing for his 12th league try of the season.
Alex Lewington pulled a try back for Irish after the interval, only for Dan Robson and Josh Bassett to put Wasps back in command, and Ashley Johnson sealed victory with the sixth try after Luke Narraway was yellow carded for Irish.
London Irish head coach Tom Coventry told BBC Radio Berkshire:
"It was a tough game, Wasps got the points that they were vying for to hopefully set themselves up for a home semi-final.
"They were pretty powerful. I thought we played well and the boys were trying their best, but at the end of the day we weren't good enough to contain them.
On the club's future following relegation: "There's a rugby department review coming up on Monday, which will be done independently.
"I'm ultimately responsible for the rugby on the field. When things aren't going well and you're not winning games, people will look for change.
"That's part and parcel of it, I understand that. As far as what that looks like, I don't have any honest answer.
"I'll probably be the first to know and then we'll get our teeth into whatever that looks like."
Wasps: C Piutau; Wade, Daly, S Piutau, Bassett; Jackson, Simpson; Mullan, Johnson, Cittadini, Launchbury, Davies, Haskell (capt), Young, Hughes.
Replacements: Shervington, Bristow, Swainston, Rowlands, Jones, Robson, Gopperth, Miller.
London Irish: Tonks; Lewington, Mulchrone, Williams, Tikoirotuma; Brophy Clews, McKibbin; Harris, Paice, Franks, Stooke, Symons, Narraway (capt), Trayfoot, Treviranus.
Replacements: Cruse, Halavatau, Palframan, Sinclair, McCusker, Allinson, Noakes, Hearn.
Referee: Tom Foley (RFU)