Joy Neville will become the first woman to referee a European professional club fixture next month.
Neville will officiate Bordeaux-Begles against Enisei-STM in Pool One of the Challenge Cup on Friday, 15 December.
The former Ireland captain and Six Nations Grand Slam winner has previously been assistant in European competitions.
She also refereed the Women's World Cup final between New Zealand and England in the summer.
Her latest progression in the men's game comes after she became one of two women to referee a men's international fixture in Europe.
Neville took charge of Norway against Denmark on 28 October, while former Spain international Alhambra Nievas refereed Finland v Norway on 14 October.
- Get all the latest rugby union news by adding notifications in the BBC Sport app.