Cardiff Blues' midweek match against tourists Uruguay on Tuesday, 6 November will be shown live by BBC Sport Wales.
Los Teros have been drawn in the same pool as Wales at the 2019 World Cup in Japan, so the fixture will give Welsh fans an early peak at the opposition.
The South American side will face Ulster in Belfast three days later, before Tests against Fiji and Romania.
"Uruguay will be at full strength and preparing for the World Cup," said Blues coach John Mulvihill.
"It will be good for us to go up against someone different, with different styles and philosophies, while exposing players to a new level of rugby.
"We face Zebre [in the Pro14] on the Sunday before this match but we will be picking the strongest possible match-day squad we can."
It will be the first time the Cardiff Arms Park side have faced international opposition since playing Australia in 2009, when the Welsh region suffered a 31-3 loss to the Wallabies.
Uruguay are among Wales' opponents for a second successive World Cup after Americas Group qualification. Georgia, Fiji and Australia are the other teams in Pool D.
Wales won the previous World Cup encounter against Uruguay 54-9 in Cardiff, with former Blues centre Cory Allen running in a hat-trick of tries in September 2015.
Los Teros qualified for the 2019 tournament by beating Canada 32-31 in their second leg of their play-off in Montevideo, sealing a 10-point aggregate margin over Kingsley Jones's side.