Celtic winger James Forrest will be handed his first Scotland cap in the Carling Nations Cup decider against Republic of Ireland in Dublin.
Blackburn central defender Grant Hanley will make his first start in place of the injured Gary Caldwell.
Sunderland's Phil Bardsley replaces Stephen Crainey at left-back.
Middlesbrough midfielder Barry Robson starts after James Morrison failed a fitness test, while Forrest is chosen ahead of Ross McCormack.
But the influential Charlie Adam has been named in Craig Levein's starting line-up despite the Blackpool midfielder having missed training on Friday and being described as an injury doubt by the national coach.
Adam and West Brom midfielder Morrison have been nursing knocks picked up in Wednesday's 3-1 win over Wales, while Wigan defender Caldwell had been struggling with a hip injury.
Bardsley's return to fitness was timely, with Blackpool's Crainey having left the squad to undergo a long-scheduled knee operation.
Levein had said on Friday: "The good thing for me is that we have a particularly strong group with us and, if I should miss a few players, I should have able replacements."
Scotland and the Republic of Ireland go into the tournament's final game having both beaten Wales and Northern Ireland and Levein will be especially disappointed to have lost the services of Caldwell and Morrison.
"We don't want to lose Gary Caldwell," he had said. "He is a very influential player and a great leader and a great example to others in the team.
"James Morrison's form has been scintillating for us any time he has played, so we don't want to lose him either.
"It's just the nature of the game. If we lose players, we lose players and we have people capable of taking their place."
The 19-year-old Forrest has yet to establish himself as an automatic pick under Neil Lennon despite becoming a regular in the Celtic first-team squad this season, but Levein was anxious to give what he considers an exciting talent his first taste of international football.
Meanwhile, Aston Villa midfielder Barry Bannan, who came on as a substitute against Wales, insists Scotland are more than capable of claiming the trophy despite Republic of Ireland being at home.
"There is no point coming here if you're not going to try to win the tournament," he said.
"We've got a great squad and we haven't had as many call-offs as the other teams.
"It shows you how seriously we are taking it. To go into the last game with something to play for makes it even better and hopefully we can turn Ireland over and win it."
The last time Scotland won silverware was the Kirin Cup in Japan in 2006 and Bannan admits they would love to come out on top again.
"There are not many opportunities for Scotland to win trophies so, when we get a chance like this, we will be going all out to win it," he said.
Bannan's enthusiasm for the task is matched by Norwich full-back Russell Martin, who made his debut against Wales.
"The lads knew, if we got the win against Wales, it would be between us and the Republic," said the 25-year-old.
"It's something to enjoy. To win any piece of silverware in your career is great and the lads will want to do it.
"Hopefully we can put in the performance and get the result."
Scotland: McGregor, Whittaker, Hanley, Berra, Bardsley, Naismith, Brown, Adam, Robson, Forrest, Miller (capt).